What's Going On

Quotes

  • mightshould:
    "I'm coping. That's a major accomplishment. Anything else is bonus."
  • Mary Rodgers:
    "So I asked the shrink: When you're depressed because of actual things that are depressing, are there any drugs that can make you feel better? And he said no, which was even more depressing."
  • David Sedaris, Happy-Go-Lucky:
    "I figured my post-college life would be pretty much like the one I'd been leading for the past decade: work some little job I didn't have to put much into, then come home and do my own stuff. It was the life that most of my friends had, and half my family." "It's a consequence of putting stuff out there--you're going to get reactions."
  • Kristina Marusic:
    "There likely aren’t a ton of people on this planet—let alone within your geography or social circles—whose moral compass, sense of humor, Netflix addictions, dietary restrictions, and idiosyncrasies sync up with yours closely enough to make you want to hitch your wagon to them for the long-haul (and the internet is making us all even picker)."
  • John Oliver:
    "Let this be a lesson that you absolutely don’t want to fuck with someone who has the patience, attention to detail, and sustained anger to crochet their resentment into a handmade garment."
  • Gail Donovan, quoted in "Knitting Yarns" in the essay "Knitted Goods"
    "I love taking what is basically a long string and constructing a three-dimensional object. I love thinking about how somebody figured out how to do that!"
  • Amber A’Lee Frost:
    "It’s not just bad for a person to rely on their weakest skills for survival; it’s unsustainable and immiserating."
  • Michael Che:
    “You know what else makes you do crazy things? Crazy,”
  • August and Annie/Isaiah, "One Last Stop."
    "Does it ever, like...I don't know. Make you lonely? To love somebody who can't meet you there?" "Sometimes. But, you know, that feeling?" When you wake up in the morning and you have somebody to think about? Somewhere for hope to go? It's good. Even when it's bad, it's good."
  • Katie Brennan:
    "The Office taught me that love isn’t always an immediate burst of rainbows and butterflies; sometimes the best kind of love is a quiet, enduring, and steadfast process. When you really love someone, you know they are worth putting in time and effort. Even if you entertain the thought of someone else during the process, i.e. you get yourself a Karen, you know they can’t compare to your person. No amount of time can make that connection fade, so whether it’s consciously or subconsciously, you wait for your stars to align. It might take your company casually hosting a Casino Night, or a heartfelt post it note attached to an Office Olympics “medal,” but eventually your time comes—and when it does, it’s pretty much the best thing ever."
  • Jane Tyson Clement:
    "We don't notice the strange way things come about while they are coming about. It is only afterwards that we see the pattern..."
  • "Candace Kahn," Almost Romance:
    "You can't blow off a good story just because it's challenging."
  • Nick Cave:
    "I prefer to say that I have made, for reasons of survival, a commitment to the uncertain nature of the world. This is where my heart lies. I suspect it always has."
  • Ted Lasso:
    "I love meeting people's moms. It's like reading an instruction manual as to why they're nuts."
  • Ask Amy:
    "My point is that you can lay out your plans, but the world might have other ideas."
  • supercrayon:
    "But I kept thinking there’s a future me a week or a month or a year away that is through this. That future me is not plagued by uncertainty, they know what happened and they’re looking back at how things played out. I liked to think that future me was sending strength and love to present me. Sometimes now, present me in fact does send strength and love back towards past me. Your future selves know what happened. The you of a week or a month from now knows, and has already started to plan your next moves. I hope strength and love are rippling up and down the timeline between yourselves."
  • Christina Long (Washington Post)
    “WHY ARE NONE OF MY INTERESTS WORTH ANYTHING IN DOLLARS,”
  • Michael Diamond:
    “People get frustrated when they can’t see the future,” says Diamond. “The future looks scary if you’re telling them it’s just staying at home for the next 12 to 18 months. You shouldn’t really be that surprised when at least a fraction of them get angry."
  • Seanan McGuire:
    "Please stop trying to solve me. I'm not a problem."
  • Morrie Morgan, in "Work Song" by Ivan Doig:
    "I don't know any cure for being myself. The lotion for that hasn't been concocted yet."
  • Jason Mendoza:
    “Sometimes you just gotta huck a Molotov cocktail at a drone and see what happens.”
  • Augusten Burroughs:
    "But impossible is a concept that makes one's heart laugh and throw peanuts at the television."
  • Augusten Burroughs:
    "Even if things aren't catastrophic now, catastrophe has always followed me. Life unfolds, right? All the time, it's unfolding, and I'm going to follow it."
  • Augusten Burroughs:
    "My life has never really been “happily ever after.” I’ve always had conflict and disaster follow me around like a shadow, and I can’t really believe that will suddenly stop now that I’m happily living in Connecticut with three dogs. We’re just going to have to see."
  • Jacqui:
    “If you have a job where you’re not coming home with stories, it’s time to leave. That simply is our qualification. Healthcare helps. Benefits are nice, but oh my god, how do you not come home with stories? It is the easiest qualification, but it’s true. My feeling is if you don’t have a story, it wasn’t a good day."
  • armeowda:
    "Many people can cast their affections broad and bright as floodlights, but others of us are laser beams, and when something actually trips our attraction/affection sensors it can feel like a certain kind of instant precision strike, and it can leave a mark forever."
  • Stan Tatkin
    "There's actually nothing more difficult on the planet than another person."
  • Lani Diane Rich:
    "What doesn't kill you makes you stranger."
  • Heather Havrilesky:
    "Do they let me write these words because I’m good at it, or do they let me do it because I’m an entertainingly crazy person who is slowly but surely unraveling before 50,000-to-100,000 sets of eyeballs each week?"
  • Justin Peters:
    "The simple lesson that Millionaire taught me is that if you want to change your life—either by winning a lot of money on television or by some more prosaic means—at some point you are going to have to take a risk. Unless you are John Carpenter, you will eventually have to step into the unknown, bet on yourself, and hope that you are making the right decision."
  • Leslie Jones
    "Women are the same as humans."
  • Anne Lamott:
    “If you’re paying attention and making your own life as beautiful and rich and fun as it can be, you might just attract someone who’s doing the same thing,” she said. “You can give up on tracking someone down with your butterfly net.” “Never give up, no matter how things look or how long they take. Don’t quit before the miracle.”
  • Seanan McGuire:
    "If what I say doesn’t help you, ask someone else, until you find the person whose reply tells you how to kick the damn door down."
  • Grangousier:
    "It's 2018. There's a realistic chance of pretty much anything happening if it's ridiculous enough."
  • Joy:
    "I feel a constant low level of stress every day, just by virtue of existing in my environment,"
  • Fancy Feast:
    "When she was on a bad date, she would go to the bathroom, hit her nose until she got a nosebleed, and excuse herself, because it was easier to punch herself in the face than suffer the consequences of rejecting a man."
  • Ber:
    "Get your freak on, screw the powers that would deny you."
  • Lee Bradford:
    "Lee? Why does all this weird shit only seem to happen to you? Well, disembodied voice from nowhere-statistically, it has to happen somewhere."
  • David Neal:
    “Nobody told us that our ‘15 Minutes of Fame’ would include shaming, insults, threats, etc. And that we might not have even asked for it.”
  • Debbie Harry (???)
    “Chaos is a great factor in making art happen."

« I'm satisfied | Main | "On at least one of these planets, Donald Trump is not president" »

February 22, 2017

Massive Brain Scan Study Reveals 4 ‘Biotypes’ of Depression

"All that number-crunching yielded four different “biotypes” of depression. They were differentiated from each other (and the control group) at a neural level. Brains whose humans had more depressive anxiety had reduced connectivity in brain networks associated with fear and understanding negative emotional stimuli; people with anhedonia — or difficulty feeling pleasure — had hyperconnectivity in brain areas associated with reward processing and motor control.

The results also sliced fascinatingly across other conditions. The researchers found that while none of the 39 people in the analysis with generalized anxiety disorder met the clinical criteria for depression, a full 69.2 percent of them “were nevertheless classified” as belonging to one of these four depression biotypes — suggesting an overlap between conditions."

Posted on February 22, 2017 at 08:50 PM in Quarterlife Crisis, Science Dorking Goodness |

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  • Lynn Sherr: Sally Ride: America's First Woman in Space
    Reviewed November 27.
  • Bonnie Garmus: Lessons in Chemistry
    Reviewed October 19. (****)
  • Gareth Russell: Do Let's Have Another Drink! The Dry Wit and Fizzy Life of Queen Elizabeth The Queen Mother
    Reviewed October 13. (****)
  • Jennifer Crusie and Bob Mayer: One in Vermillion
    Reviewed October 12. (***)
  • Michael Schulman: Oscar Wars: A History of Hollywood in Gold, Sweat and Tears
    Reviewed October 2. (****)
  • Jesse Q. Sutanto: Vera Wong's Unsolicited Advice for Murderers
    Reviewed September 22. (****)
  • Katie Cotugno: Birds of California
    Reviewed September 16. (***)
  • C.K. Chau: Good Fortune
    Reviewed September 13. (***)
  • Aimee Lutkin: The Lonely Hunter: How Our Search For Love Is Broken
    Reviewed September 10. (***)
  • D.L. Soria: Thief, Liar, Lady
    Reviewed September 9. (****)
  • Taylor Jenkins Reid: Carrie Soto Is Back
    Reviewed September 8. (****)
  • Taylor Jenkins Reid: Malibu Rising
    Reviewed September 4, 2023. (****)
  • Lana Harper: Back In A Spell
    Reviewed September 4. (***)
  • Lana Harper: From Bad to Cursed
    Reviewed August 31. (***)
  • Edward Sorel: Mary Astor's Purple Diary: The Great American Sex Scandal of 1936
    Reviewed August 20. (***)
  • Anna Sortino: Give Me A Sign
    Reviewed August 18. (***)
  • Ashley Poston: The Seven Year Slip
    Reviewed August 10. (****)
  • Jennifer Crusie and Bob Mayer: Lavender's Blue
    Reviewed July 30. (****)
  • Katherine Center: The Bodyguard
    Reviewed July 17. (****)
  • Kate Quinn: The Diamond Eye
    Reviewed July 15. (****)
  • Maureen Ryan: Burn It Down: Power, Complicity, and a Call for Change in Hollywood.
    Reviewed June 13. (*****)
  • Julie Murphy and Sierra Simone: A Merry Little Meet Cute
    Reviewed June 13. (***)
  • Katharine McGee: American Royals III: Rivals
    Reviewed June 12. (***)
  • Stacy Wolf: Changed For Good: A Feminist History of the Broadway Musical
    Reviewed June 5. (****)
  • Jen DeLuca: Well Traveled
    Reviewed June 4. (****)
  • Nan Fischer: Some Of It Was Real
    Reviewed May 15. (****)
  • Sangu Mandanna: The Very Secret Society of Irregular Witches
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    Reviewed May 10. (****)
  • Aminatou Sow and Ann Friedman: Big Friendship: How We Keep Each Other Close
    Reviewed May 9. (***)
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    Reviewed May 8. (***)
  • Robert Dallek: An Unfinished Life: John F. Kennedy, 1917-1963
    Reviewed April 23. (**)
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    Reviewed April 20. (***)
  • Alan Brinkley: John F. Kennedy
    Reviewed April 14. (**)
  • Jennifer Lynn Barnes: The Final Gambit
    Reviewed April 10. (****)
  • Mary Robinette Kowal: The Spare Man
    Reviewed April 8. (****)
  • Andrew Lownie: Traitor King: The Scandalous Exile of the Duke and Duchess of Windsor
    Reviewed April 4. (***)
  • Shonda Rhimes and Betsy Beers: Inside Bridgerton
    Reviewed April 3. (****)
  • Jennifer Estep: Conquer the Kingdom
    Reviewed April 2. (***)
  • Seanan McGuire: Backpacking Through Bedlam
    Reviewed March 18. (****)
  • Kate Andersen Brower: Elizabeth Taylor: The Grit and Glamour of an Icon
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